Medibrane utilizes various technologies and, where needed, combines multiple techniques to achieve the precise results required for each device or structure.

Surface treatment

Surface treatment

Preparing the device’s surface is essential for obtaining good adhesion of the coating or of the implantable device. We implement the following pre-treatment surface techniques:

Grit-blasting: By forcibly propelling a stream of sand at high pressure against the stent’s metallic surface, the smooth surface becomes porous, which improves the adhesion of the coating to the surface.

Corona treatment (Air plasma): When utilizing this technique, a low-temperature, high-voltage electrical discharge is applied to an electrode that has a sharp tip, causing corona plasma to form at the tip. A linear array of electrodes is used to create a curtain of corona plasma, which modifies the stent’s surface.

Chemical treatment: This highly-effective method uses strong acids, alkalis, or mixtures of oxidants which remove thin layers of the surface, resulting in roughening of the surface, as well as causing surface porosity, which facilitates adhesion of the coatings.

Bonding molecules: In this technique, a base coating layer is created from bonding molecules, which one side adheres to the substrate, while the other side adheres to the coating.

Dip coating and molding

Dip coating and molding

Utilizing state-of-the-art machinery and precisely designed manufacturing processes, we are able to control temperature, humidity and viscosity, and achieve high manufacturing yield, while overcoming the challenging aspects of this technique, such as  non uniform coatings, bubbles, low  adhesion and high defect rate.

Advantages over other techniques:

  • Fast prototype development
  • Cost effectiveness
  • Coatings with wall thickness of between 10-100 microns
  • Coating Tolerance: ± 10 microns

Spray coating

Spray coating

The spray coating technique utilizes ultrasonic nozzles, enabling good control over the  coating's properties ,  ,  easy to adapt it and easy  tailoring   to applications require thin uniform

Advantages over other techniques:

  • Easy shaping of sprayed patterns, to achieve to achieve to applications require thin

uniform precise coating applications

  • Highly uniform surfaces are required particularly for cardiovascular devices,

Neurovascular and peripheral devices.

  • Solvents are highly sensitive to dipping, and spray coating is used instead
  • Highly controllable spray produces reliable, consistent results
  • Coating wall thickness: 10-100 microns
  • Coating Tolerance: ± 3 microns


Spray coating
Farhatnia Y1, Tan A, Motiwala A, Cousins BG, Seifalian AM. Biotechnol Adv. 2013 Sep-Oct;31(5):524-42. Evolution of covered stents in the contemporary era: clinical application, materials and manufacturing strategies using nanotechnology.


Electrospinning is a fiber production method which uses electric force to draw charged threads of polymer solutions to fiber diameters.
The electrospinning manufacturing process comprises of surface treatment sequence that enables strong adhesion forces between the substrate and the coating layer.
The end result is a fully encapsulated cover without any exposed metal surfaces.

 Fiber diameter range: 2 – 300 [nm]
 Porosity definition: 2-40 [nm]

Differentiations in pore size can impact :

• Tissue regrowth
• Cell adhesion
• Migration
• Proliferation

The main clinical application for this technology are in structural heart and peripheral angioplasty.